Nankai university to reveal the mechanism of Chinese traditional medicine to provide new research ideas

The 2014-07-22 14:26:21 source: southern net author: Zou Changsen increase with the decrease of size size

        Recently, nankai university, computer and control engineering, pharmacy, life sciences joint research team the latest achievements of the filter using zebrafish behavior has the neural activity of traditional Chinese medicine prescription and biological targets ", published in the journal Scientific Reports of Nature publishing group (DOI: 10.1038 / srep05311). The results to reveal the mechanism of traditional Chinese medicine provides a new research ideas, and understanding of western science, Chinese traditional medicine prescription. 

        The southern network - , according to nankai news recently, nankai university computer and control engineering, pharmacy, life sciences joint research team the latest achievements of the filter using zebrafish behavior with neural activity prescription of traditional Chinese medicines and biological targets ", published in the journal Scientific Reports of Nature publishing group (DOI: 10.1038 / srep05311). The results to reveal the mechanism of traditional Chinese medicine provides a new research ideas, and understanding of western science, Chinese traditional medicine prescription. 
 
        "Western pharmaceutical standards are for the western medicine, what is composition, content is how much, what is the mechanism of work, are required to have clear, according to data but these requirements for Chinese traditional medicine is difficult to achieve, especially mechanism." Nankai university college of life science, drug fengxi increase of state key laboratory of chemical biology professor said. 
 
        In order to solve this problem, nankai university joint research team carried out based on the similarity of zebrafish genes with human behavior analysis, explore the antidepressant medicine prescription effect on zebrafish sleep/wake behavior, combined with the known western medicine using the correlation analysis to predict Chinese medicine prescription effect research of neural pathways. 
 
        Nankai university college of pharmacy, medicine of the national key laboratory of chemical biology professor white steel provides the radix bupleuri liver powder, gansu wheat jujube soup, such as peach siwu pill seven classic antidepressant Chinese traditional medicine prescription, and by using high pressure liquid - mass spectrometry combined analysis, every recipe contains a variety of chemical composition. Then, researchers to four days of zebrafish larvae feeding different traditional Chinese medicine (TCM), after a period of time, zebrafish round, activity, sleep and other behaviors are obvious change. 
 
        Research team using computer and control engineering college of nankai university, robot and information automation institute professor zhao new team designed and developed a set of video tracking and data transformation system, after dosing of the zebrafish real-time movement and depth of the data mining. "So that we get the seven on the impact of Chinese traditional medicine prescription on zebrafish sleep/wake behavior massive behavior data." Joint research team members which park band said. 
 
        With known antidepressants figures on the impact of western medicine on zebrafish behavior after comparing analysis, the researchers found that these Chinese traditional medicine prescription and some targets have been very clear western medicine has a highly similar behavior influence on zebrafish. On this basis, the scientific research team to predict the mechanism of action of these seven Chinese traditional medicine prescription. "For example, we found that the traditional Chinese medicine (TCM) wheat jujube soup with classic antidepressant Max Planck for Lin is similar behavior data, suggesting they through common neural signaling pathways work. Later, we will be targeted by experiments verified." Which park band said. 
 
        Through this behavior means to high flux, quickly and reliably to psychiatric drugs screening and evaluation, not just confined to antidepressant prescriptions of Chinese medicine, this to explain the mechanism of traditional Chinese medicine (TCM) provides a new train of thought and ways. 
 
        It is understood that the study by the national natural science foundation project scientific instruments basic study major projects, national natural science foundation of state key laboratory of chemical biology and drug open fund of funds. Periodicals "Scientific Reports" is a comprehensive science journal Nature publishing group, the focus for multidisciplinary cross research, in the international journal of comprehensive 8th.