With the overall view understand traditional Chinese medicine compound 
 
 
The 2015-04-02 14:09 
 
 
Source: China's traditional Chinese medicine 

    Traditional Chinese medicine compound is a major means of traditional Chinese medicine to treat disease, is the basis for the development of new drug of TCM, and an important source. Statistics show that China has approved the proprietary Chinese medicine is more than 90% of the varieties was developed on the basis of traditional Chinese medicine compound, such as the well-known san-jiu tiger bones, joints, stomach pills, compound danshen dropping pill, stomach Sue particles, tongxinluo, etc., many drugs on the market, finally developed into more than 1 billion yuan annual sales of large variety.
 
    Traditional Chinese medicine compound is a major means of traditional Chinese medicine to treat disease
 
    But the team should also see, in a number of proprietary Chinese medicine, clinical application widely, huge market share and study with higher levels of species rare, this led directly to the our country market competitiveness in the international Chinese medicine variety, Japan, Korea, southeast Asia, Europe and other countries "foreign Chinese medicine" in just a few years time to break into the Chinese market has proved a good one.
 
    Investigate its reason, the biggest technical bottleneck is the problem that traditional Chinese medicine compound medicinal material research, traditional Chinese medicine compound is difficult to realize due to drug substance is not clear pursuit, cause quality control difficult, difficult to optimize preparation process, seriously affect the curative effect and patient compliance, greatly restricted the development and application of traditional Chinese medicine compound.
 
    Careful analysis of the clinical curative effect of internationally recognised of traditional Chinese medicine compound, its efficacy material studies very well, such as in the United States in 2013 to complete Ⅱ phase of clinical trial of the centralizer blood, professor liu ping, vice President of Shanghai university of TCM group after more than 40 years of research, found that the total of 23 different polarity of centralizer blood into the blood components, and confirmed the centralizer blood components nine main effect, but also clear the three mechanisms of its anti liver fibrosis: reduce liver cell damage, inhibit the activation of hepatic stellate cells, restore liver matrix structure. It is these research results has been billed as the world's most rigorous FDA drug safety institutions, centralizer blood piece to clinical trials in the United States to carry out the international standard, finally obtained the world recognized clinical trial results.
 
    Professor zhang wd at the second military medical university school of medicine and the university of Cambridge professor fan flat machine, common confirmed in the heart of musk pills 40 70 non-volatile components and volatile components, and 22 prototype into the blood components, 8 metabolites, and further reveal the role of the heart of musk pills pathways and targets, this foundation to reveal the effects of the hearts of musk pills and molecular mechanism provides an important basis. This not only shows the heart of musk pills of scientific and technological innovation has been walking in the forefront of the world, more proved by heart of musk pills compound traditional Chinese medicine (TCM) is received extensive attention of the world.
 
    Therefore, research on traditional Chinese medicine compound medicinal material, which is beneficial to solve the compound Chinese medicine efficacy composition, mechanism of action of unknown difficulties, for revealing, targets and mechanisms of action of traditional Chinese medicine compound compatibility of the law, such as scientific connotation, promoting is the result of clinical Chinese medicine compound new drug research and development, improve the level of clinical treatment is of great significance.
 
    Clinical phenotypes for drug screening index
 
    Traditional Chinese medicine compound medicinal material research has long been subject to the following technical difficulties:
 
    (1) lack of to adjust and reflect the overall Chinese medicine compound ingredients, animal model, the characteristics of the target is the medicinal material research results to reflect the characteristics of the compound primary reason;
 
    (2) of traditional Chinese medicine compound prescription, ingredients, its efficacy material research extremely difficult;
 
    Drugs play a role of root lies in the composition and the environment interaction in the body
 
    (3) the drug is components of function and environment of interaction in the body, so the essence of the medicinal material research is to find and identify associated with efficacy, the active ingredient, however, traditional Chinese medicine compound containing hundreds of components, how to fast and efficient screening active ingredient is always associated with efficacy of traditional Chinese medicine compound medicinal material research of the key factors.
 
    Traditional medicinal material research methods both effective guide and component oriented, finally both need a great deal of monomer by screening efficacy study, time is long, high cost, low efficiency, more important is the traditional method will effect and the components separated, has violated the holistic concept of TCM, difficult to reveal the traditional Chinese medicine compound ingredients and targets for overall adjustment, also can't reveal the inner relations of compound fujin made as a result of natural and hard to reflect the effect of traditional Chinese medicine, especially difficult to reveal its scientific connotation.
 
    So based on the guidance of TCM theory, constructs the accord with the characteristics of the overall concept of traditional Chinese medicine and traditional Chinese medicine compound research strategy and the technical method, is the key to solve the modernization of traditional Chinese medicine compound development problems.
 
(health)