"Available kyushin pills" behind the story of the hero

On November 6, 2015

Source: the order of the phoenix of traditional Chinese medicine

Abstract: it is the only national varieties of a state secret "available kyushin pills", the renowned at home and abroad of traditional Chinese medicine dropping pill, it is the inventor of a halfway decent, after work to study the TCM theory of traditional Chinese medicine experts; She is the tianjin new pharmaceutical group co., LTD., chief technical expert, professor ZhangChen guangxi senior adviser for the rest of my life.

Tu's success is no accident

On October 5, 2015, Chinese scientists tu to share this year's Nobel Prize in physiology or medicine; As the first Chinese won the Nobel natural science, the outstanding contribution of tu is created the new antimalarial drug artemisinin - artemisinin and double hydrogen.

In 1969, tu and her leadership team of the first in more than 2000 kinds of formulas containing compiled a more than 640 kinds of herbs antimalarial agent for collection, low boiling point in the 191th time since experiments found antimalarial effect for 100% of artemisinin;

In 1972, the active ingredients extracted from the extract of antimalarial artemisinin.

In 1992, about the high cost of artemisinin, shortcomings and so on to malaria is difficult to cure, tu and invented the double hydrogen artemisinin the antimalarial efficacy for the former is 10 times "upgrade".

Tu won universally acknowledged achievements of many factors, but the following are two of the most important:

(1) the age factor. Specific era, that allows her to allocate resources across the country, benefit from the trans-regional, cross-sectoral coordination;

(2) spiritual power. The older generation of pharmaceutical scientists largely indifferent to fame and wealth, career perseverance and dedication.

Do you know? "Available kyushin pills" behind the scenes hero - ZhangChen laurel, professor is coming from that particular s medical technology experts.

ZhangChen laurel -- "available kyushin pills" behind the hero

It is the only national varieties of a state secret "available kyushin pills", the renowned at home and abroad of traditional Chinese medicine dropping pill, it is the inventor of a halfway decent, after work to study the TCM theory of traditional Chinese medicine experts; She is the tianjin new pharmaceutical group co., LTD., chief technical expert, professor ZhangChen guangxi senior adviser for the rest of my life.

ZhangChen guangxi in 1958, graduated from nanjing college of pharmacy (now China pharmaceutical university), medicinal materials company after graduation was assigned to tianjin, has close relationship with Chinese traditional medicine, from now on start to QiHuang road. ZhangChen laurel under well-known pharmacist Tian Shaolin, ke-rang zhang, began to the exploration of new pill improved traditional research; Then visited Lin Qishou into Beijing, RanXiaoFeng, such as traditional Chinese medicine for advice modestly, study. After nearly 20 years, she took root production line of scientific research, studies of traditional Chinese medicine theory knowledge, to explore in the field of new traditional Chinese medicine research and development, accumulated experience, broaden the knowledge field; ZhangChen laurel proposed the scientific research of TCM and three goals: one is less dose, significant efficacy, side effects, the smallest suits, transport, storage facilities; 2 it is to the quick, efficient and effective "three-way" dosage form in the direction of development; 3 it is to the directional and quantitative, timing, controlled release drug delivery system development. And available kyushin pills is a master of the above three research objectives.

ZhangChen cassia from hundreds of promoting blood circulation to remove blood stasis by animal screening prescription medicine, after pharmacological research, advanced separation technology and a variety of process condition experiments, and scientific data obtained on the basis of a large number of clinical validation, available has been successfully developed, easily absorbed by the mucous membrane, small dose and portable miniature dropping pill dosage form - available kyushin pills. In 1983, quick-acting kyushin pills first no.6 middle school in tianjin pharmaceutical factory production, become China's first large-scale production and clinical popularization application of traditional Chinese medicine dropping pill dosage forms. The sales reached 1.13 million bottles.

Available kyushin pills in the process of the invention has an interesting story. Once, ZhangChen laurel available kyushin pills and nitroglycerin effect contrast test, nitroglycerin oral 2 minutes to take effect, and their available kyushin pills to animals, after taking 10 minutes passed, and don't see the obvious effect. At that time, ZhangChen guangxi through the heart of the cold, "doesn't work, thanks to years of efforts in vain? Exactly wrong where?" ZhangChen laurel thinking, colleagues see her face very dignified. After check carefully observation data, she found about the medicine for 5 minutes or so, the instrument has been recorded with the same effect of nitroglycerin drug reaction, just because observation personnel negligence does not see, the success of their research is stand up to scrutiny, ZhangChen laurel and colleagues that smile, relieved. More importantly, before 1983 drugs in the treatment of cardiovascular disease is mainly nitroglycerin, but side effects are too large; And the available kyushin pills is nearly non-toxic side effects, clinical application of thirty years, and no obvious adverse reactions.

Instant success of kyushin pills is founded the formula screening to determine, dosage form selection, production process reengineering, the drug pharmacology experiment and so on various research and development production, a set of perfect system, for traditional Chinese medicine modernization provides a benchmarking and using for reference.

The reason of ZhangChen laurel

In 1988, after the success of the new type of proprietary Chinese medicine available kyushin pills, ZhangChen guangxi to the university of Antwerp, Belgium medical research at a visiting scholar, for new drug development work. In Belgium, was assigned to her is the extraction of coarsening drug, but due to late, can only let her and other colleagues to burns medicine is for external use only, she is responsible for the study of biological cells in vitro screening. ZhangChen laurel assure the factory director, after a year and a half technology must return home after their graduation.

On the appointed time, ZhangChen participate in guangxi had finished study of the topic, research at the university tutors to retain, hope she can stay at work abroad for a long time, are willing to give her a laboratory, with two assistants. If determined to return home, in the future scientific research achievements into production was not her share, even paper also not her name, this will mean ZhangChen laurel attendance of working abroad, but she still had the performance return home.

Back in a few years, ZhangChen guangxi have the opportunity to declare academician in Belgium research projects, published by the international pharmaceutical research department has its own name on the paper, she could be elected academicians. "But I do not regret it, not for money, don't, have no have no." ZhangChen laurel said.

Well-paid ZhangChen guangxi declined several times abroad, steadfastness, for Chinese medicine services paid in our country, its contribution. Successively served as the standing committee of the national pharmacopoeia committee, the ministry of health and the national drug supervision and administration of new drugs, traditional Chinese medicine (TCM) varieties protection review committee, many colleges and universities, a visiting professor, doctoral tutor. Is the personnel department, the ministry of health, the administration of traditional Chinese medicine and old Chinese medicine expert DaiTu mentor, who won the national advanced merit female worker, 85 MEDALS, city "38" worker and so on many honors.