Reveal the traditional Chinese medicine active ingredients have new recruit

Time: 2016-02-05

Source: China's traditional Chinese medicine

Author: hallen

Traditional Chinese medicine and natural medicine chemistry and biological activity of research is to clarify the scientific connotation of traditional Chinese medicine treating diseases and the modernization of traditional Chinese medicine (TCM) premise and foundation. And separation of active ingredients in natural drugs is a major hurdle, in the study of large workload, poor pertinence and high repetition rate, makes it hard for active ingredient separation efficiency improved.

Vice principal kong ly led the team of China pharmaceutical university, after 20 years of efforts, to create a series of chromatography and spectral technology to connect the preparation of separation and structural identification of integration of traditional Chinese medicine and natural medicine chemistry new technology of separation and found that the bioactive compounds with novel structure. The application of new technology accelerated the pace of Chinese traditional medicine research and development material base, promotes the modernization and internationalization of traditional Chinese medicine (TCM), won the national scientific and technological progress second prize in 2015.

To explore Chinese medicine chemical separation technology

Sample loss and separation efficiency is lower in the study of natural medicine chemistry in the way. In the 1980 s, American scholar research and development of a high speed countercurrent chromatography, with no solid support, according to the physical distribution coefficient of the difference in the two phase separation was carried out on the material, to avoid the traditional chromatography caused by irreversible sorption of sample loss, inactivation, degeneration and so on, can not only make the sample all recycling, recycling samples can more reflect its original characteristics, especially suitable for the separation of natural bioactive components.

Kong ly lead the team to carry out high speed countercurrent chromatography separation in the preparation of all kinds of traditional Chinese medicine (TCM) the applicability of the active ingredient research, creative type to the preparation of chromatographic separation technology (HSCCC, HPLC, MPLC) and spectrum (MS) connection technology, the preparation of chromatography and spectral technology automatically connected separation and structural identification of integration of traditional Chinese medicine and natural medicine chemistry separation series of new technologies, natural significantly increased the isolation of the active compounds with novel structure level.

This technology can promote Chinese medicine material foundation to clarify, based on traditional Chinese medicine and natural medicine active ingredients of drug discovery, the improvement of the traditional Chinese medicine quality control standards and improve the aspects of research work. Apply new technology to drug research and development and production practice, can effectively improve the level of drug discovery and solve the key technical problems, provide strong technical support to the Chinese medicine industry in our country.

Based on the Chinese native medicine ingredient research of new technology

Over the years, application of new techniques, kong ly led the team from more than 60 kinds of traditional Chinese medicine and natural medicine were isolated and identified more than 5000 compounds, discovered more than 600 new compounds, among them 25 new skeleton compounds. At the same time, established the Chinese medicine and natural medicine compound libraries, in traditional Chinese medicine and natural medicine research and development play an important role.

In addition, the project system researches on biological activity of compounds, illuminates the part of traditional Chinese medicine and medicinal plants the material basis for the clinical treatment of diseases, have fall blood sugar was determined, anti allergic asthma, and other significant activity of antitumor compounds in 42, and for the development of new drugs with independent intellectual property rights laid the foundation, two compounds are classified as national major projects of science and technology major drug discovery drug candidates.

Team will be separation of new technology application to the study of chemical reference substance of traditional Chinese medicine preparation, also has obtained the good effect. The separation and preparation of chemical reference substance of traditional Chinese medicines are applied to the Chinese pharmacopoeia 2010 edition of the quality control study, drafting the quality standards of the 12 Chinese traditional medicine and yinpian, which has been issued and implemented, the improvement of the quality control standard for traditional Chinese medicine and improve made an important contribution to ensure that the relevant clinical application of the safety and efficacy of traditional Chinese medicine (TCM).

Project authorization, the eight patents published SCI included 116 papers, including 30 papers published in chromatographic separation and natural products research in the field of international authoritative journals. Related work has won the first prize in science and technology prize of jiangsu province in 2013, 2009 the ministry of education natural science prize.