Poison and blood stasis of TCM for myocardial infarction (ami) issued a "flare"

The 2016-02-25

Source: health

- our reporter Cui fang correspondent Li-li wu -

In recent years, the incidence of coronary heart disease (CHD) showed a trend of rising year by year and younger in our country, such as myocardial infarction acute coronary events not only become the people of the main causes of death and disability, also let family economic and national health spending a heavy burden on his back. How high of acute coronary events "flares", hit the brakes? By the China academy of traditional Chinese medicine xiyuan hospital, china-japan friendship hospital jointly, 10-year completed "coronary heart disease and blood stasis poison etiology and pathogenesis of innovation system research" with a doctor of traditional Chinese medicine prescriptions. The study has won the 2015 national science and technology progress second prize.

A mystery of a stabilization of coronary heart disease

Chinese academy of engineering, China academy of traditional Chinese medicine xiyuan hospital cardiovascular disease expert ke-ji Chen, nearly 10 years had a troubled: clinically, the doctor often coronary heart disease can be divided into stability of coronary artery disease and acute coronary syndrome, and points and corresponding treatment measures. But some of it is in the traditional sense of the stable coronary heart disease, why also cardiovascular emergency, let a person available?

"In order to solve this problem, the treatment methods of modern medicine is more also. Given the coronary heart disease is coronary arteries atherosclerosis lesions caused by vascular cavity stenosis or occlusion, cause myocardial ischemia, hypoxia or necrosis caused by heart disease, and unstable plaque rupture and subsequent thrombus formation is the main pathological basis of acute coronary events, western medicine generally can give patients taking statins stable plaques. But even so, there are 5% ~ 10% stabilization in patients with unstable angina pectoris of coronary heart disease, myocardial infarction (mi)." Xiyuan hospital, Chinese medicine, vice President of the cardio-cerebrovascular disease expert s large zhuo analysis. How to play to advantages of Chinese medicine, the effective early warning, to reduce this kind of incident? Under the guidance of ke-ji Chen, by researchers at the xiyuan hospital, china-japan friendship hospital related team began to explore the trip.

Previously, the major is generally believed that main etiology and pathogenesis of coronary heart disease is blood stasis. But with coronary heart disease patients with blood stasis syndrome, some long-term, stable, but some acute event happened, I'm afraid the single blood stasis is difficult to explain. Is the occurrence of acute coronary events and the Chinese medicine "poison" to cause the sudden strong and rotting flesh meat characteristics are very similar. Will such patients due to blood stasis for a long time, etiology and pathogenesis of transformed, "due to blood stasis, caused by tainted blood stasis, blood stasis poison each knot disease", which can lead to coronary heart disease (CHD) of acute cardiovascular events?

Followed this hypothesis, the team in 1000 old Chinese medical books "stasis poison" retrieval "poison", according to the retrieval system summed up the "blood stasis poison" the pathogenic characteristics, clinical manifestations and related indicators, and clinical verification, the research into.

Large sample study diagnostic criteria

To verify the reliability of stasis poison hypothesis, the team first big samples using prospective cohort study, in 1503 cases of coronary heart disease (CHD) stabilization are diagnosed by coronary angiography, because by card, comprehensive analysis, summarizes the patients clinical characterization and the physical and chemical indicators of "poison". Then, these patients according to this standard can be divided into accord with inconsistent because of toxic pathogenic group and form, calculate the cardiovascular risk of thromboembolism event happened and attributable risk.

Results show that in line with the group events of 63 patients with 786, risk by 8.02%; Does not conform to form 717 9 cases, events that can occur in patients with risk of 1.26%. "This suggests that this standard can be used for the identification of patients at high risk of coronary heart disease (CHD) stabilization and poisonous pathogenic diagnosis." Research experts, xiyuan hospital cardiovascular disease center, deputy director of xiho is introduced, the researchers indexes related to the clinical study of comparison and analysis, combined with traditional Chinese medicine about due to poison the understanding of the disease, according to the history, symptoms, signs, tongue, pulse condition, different variables such as physical and chemical indicators of risk ratio to determine the weights, further refined, made the patients with coronary heart disease (CHD) stabilization due to toxic pathogenic diagnosis and quantitative standard, including six main index, six secondary indicators. Among them, the main indicators include moderately severe angina pectoris, severe mouth bitter, old tongue, tongue green or blue, peel moss, the symptom such as purple or dark reddish purple sublingual collaterals and tongue in TCM.

On this basis, the research further stability to 40, 2700 hospital after interventional coronary heart disease patients, using diagnostic test evaluation method, through the sensitivity, accuracy and a series of evaluation, specific degree, test and verify the reliability of the standard, confirmed coronary heart disease (CHD) stability because of poisonous pathogenic differentiation diagnosis of quantitative standard for diagnosing poison to cause higher veracity, reliability, to identify the high risk population in patients with stable, has high clinical value.

The presentation will still be amplification multiple research

Experts review work in ten years, the group said that although the process is long and hard, but fruitful. "We first put forward stasis poison causes theory, theoretical system; innovation the etiology and pathogenesis of coronary heart disease in which scientific validation process, established the combined disease pathogenesis research new mode; after that, we also further illustrates the coronary heart disease 'blood stasis poison into the pathogenesis and syndrome evolution law, etc." Shi zhuo said, the most important thing is that the original intention of the study, after the late achievement promotion, "we are more and more realized by way of traditional Chinese medicine medical institutions effective identification of high-risk groups, early warning, to further reduce the cardiovascular events as a force".

And theory innovation, the validation of the follow-up effect is the improvement of the treatment. Learned, always coronary heart disease (CHD) research and development of traditional Chinese medicine by promoting blood circulation to remove blood stasis syndromes as the breakthrough point, low level repeated more, as the "stasis poison" the theory of etiology and pathogenesis of coronary heart disease, opened a new direction of research and development of new drug of TCM. "Given the incidence of coronary heart disease high and hospitalization rates, on the basis of the principle of 'blood stasis poison of invigorate the circulation antidote will have broad application prospects." Xiho is introduced, the next step, the project will be through the invigorate the antidote intervention in high-risk groups, to verify the effects of reducing cardiovascular events. And on a study and analysis of some further sub-classified guess about stasis poison, will also be verified in the future.