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Heart protection first lipid
2017-02-05
Health News
Lipid metabolism, atherosclerotic cardiovascular and cerebrovascular disease is an important risk factor. The intervention of dyslipidemia is an important measure to prevent coronary heart disease, stroke and other vascular diseases.
Why LDL is the most critical lipoprotein is the main material transport of lipids. Lipids in the body's use, transformation and metabolism, that is, lipoprotein metabolism. Plasma cholesterol, especially low-density lipoprotein cholesterol (LDL-C), is the development of atherosclerosis, a necessary condition. Animals with LDL-C less than 2.1 mmol / L (80 mg / dl) generally do not develop atherosclerosis. Epidemiological studies have shown that serum LDL-C levels are associated with atherosclerotic cardiovascular and cerebrovascular events, and atherosclerosis is associated with atherosclerosis and atherosclerosis.
At present, domestic and foreign dyslipidemia treatment guidelines, will LDL-C as the primary goal of lipid-lowering therapy. For patients with very high risk of cardiovascular disease, such as diabetic vascular disease or acute coronary syndrome, domestic treatment guidelines recommend lowering LDL-C to less than 2.1 mmol / L (80 mg / dl).
Why High Density Lipoprotein Protects Blood Vessels
High-density lipoprotein (HDL) is an important anti-atherosclerotic substance that blocks arterial atherosclerosis in multiple processes.HDL has the most precise protective effect on promoting cholesterol efflux in arterial wall cells, Run to the liver after removal, thus play the role of anti-atherosclerosis. HDL also has antioxidant, anti-inflammatory, protective vascular endothelial cells and improve coagulation / fiber imbalance and other aspects of function. Epidemiological studies of high-density lipoprotein cholesterol (HDL-C) levels, and atherosclerotic cardiovascular and cerebrovascular events showed a negative correlation, and this correlation does not depend on changes in LDL-C levels.
Why lipid deposition in the blood vessel wall
The deposition of lipids in the vessel wall is a fundamental process of atherosclerosis. Hypertension, lipid abnormalities, diabetes, smoking and other risk factors, can cause vascular endothelial injury, damage the integrity of the endothelium. C through the damaged endothelium into the subcutaneous, macrophages phagocytosis of LDL-C after the formation of foam cells, and deposition in the subcutaneous formation of lipid streaks and atherosclerotic plaques. Therefore, a variety of cardiovascular risk factors for vascular endothelial injury, lipid deposition in the vessel wall to create the conditions, and LDL-C is the most basic form of atherosclerotic plaques.
Why do lipids from the beginning to change the way of life
Regulating the content of fatty acids, lowering the concentration of lipoprotein cholesterol and lowering the concentration of lipoprotein cholesterol. Ester (a secondary target for treatment therapy).
Elevated mannatriol and decreased HDL-C, by diet, weight loss and physical activity and other factors. A person's triglycerides at 150 ~ 199mg / dl, the first treatment should be used to improve the way of life. For hypertriglyceridemia and HDL-C is too low, lipid-lowering treatment should be to control weight as one of the main means. In addition to restrictions on dietary fat, sweets and other high-calorie foods should increase physical exercise, such as walking, jogging, doing gymnastics, swimming, cycling, etc., every day for 30 to 40 minutes of standardized aerobic exercise to achieve calories Access to balance, weight loss, while appropriate control of staple food.
Epidemiological studies have found that people engaged in sports and heavy manual labor with the same age, fewer physical activity compared to serum cholesterol and triglyceride levels should be low, and high levels of high-density lipoprotein cholesterol. Therefore, long-term, regular exercise, the regulation of blood lipids have a significant effect. Appropriate long-term exercise, can reduce blood lipids, promote lipid metabolism, improve lipoprotein lipoprotein activity, accelerate the operation of lipid, decomposition and excretion. In addition, exercise can improve the body's glucose metabolism, blood clotting state, platelet function, and can improve myocardial function, enhance myocardial metabolism, and promote the establishment of collateral circulation, which are the prevention and treatment of coronary heart disease has a positive significance.
Fat is one of the important energy sources, but also the structural components of cells and many synthetic hormones raw materials. However, excessive intake of fat, fat can also be deadly accumulation in the body, causing obesity, high blood lipids or a variety of cardiovascular and cerebrovascular diseases, a reasonable diet, is based on activity, the daily total calories in 2000 ~ 2500 card. For less active, frail elderly and people with excess nutrients related diseases, total calories also reduced.