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Food effects

      Food can increase the absorption rate and bioavailability of food can reduce the rate of gastric emptying, prolong the residence time of drugs in the stomach, is conducive to the absorption of insoluble drugs. In addition, food (especially fat foods) can promote bile secretion, bile with emulsification, can increase the absorption of fat-soluble drugs. For example, after taking griseofulvin, compared with fasting, low-fat meal and high-fat meal can increase its absorption rate of 70% and 120%. Such drugs are also propranolol (propranolol), metoprolol, spironolactone, phenytoin, carbamazepine, dicoumarol, vitamin A, ketoconazole, etc., meals or meals after taking these drugs can be improved Efficacy. In addition, help digestion drugs and gastrointestinal irritation of the larger drugs, should also be taken after meals. The following are the same as the "
      Food can reduce the rate of absorption and bioavailability of food can reduce the rate of gastric emptying and increase the residence time of the drug in the stomach, which can dissolve faster or acid-labile drug breakdown damage increased. In addition, some substances in food have a role in the adsorption of drug molecules, thus reducing the absorption of drugs. For example, after taking tetracycline drugs, the plasma concentration than the empty stomach will be reduced by 50% to 80%. After taking bercatipril, its plasma concentration can be reduced by 35% to 4O% compared with the empty stomach, and the time required to reach the highest blood concentration is also delayed for 1 hour. Drugs that are susceptible to food and reduce the efficacy of drugs also include fumedate (enteric-coated tablets), lei Feng, rifampicin, erythromycin, ampicillin, amoxicillin, oral cephalosporins, penicillamine And Nicardia.

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