Create a new road of science and technology research and development for the endangered Chinese medicinal materials

The 2016-02-04 and

Source: journal of science and technology

S innovation of revelation

Artificial substitute of endangered Chinese traditional medicine research needs huge investment and long cycle, artificial musk started first, followed by artificial cultivation bezoar and so on in vitro in China have also made important progress

Recently, "artificial musk development and industrialization" project was awarded the first prize for 2015 state science and technology progress prize, this is China's first with independent intellectual property rights of synthetic endangered medicinal materials substitutes, it created the artificial replacement of endangered medicinal materials, also drove the artificial tiger bone powder, in vitro cultivation bezoar and so on a series of research and development, the promotion of endangered medicinal materials substitutes. The personage inside course of study thinks, the success of the development and industrialization of artificial musk is one of the important direction of research and development of traditional Chinese medicine, Chinese medicine modernization in the future.

It is very urgent to protect the endangered species Chinese medicine

"Tradition is the quintessence of traditional Chinese medicine, also is the advantage industry", and that everything is based on the rich resources of medicinal, if did not have these resources, traditional Chinese medicine has become bricks without straw, traditional Chinese medicine development. Because of the ecological system changes, China's many species have become endangered species and a vulnerable species.

Statistics show that at present, the endangered species in higher plants, 4000-5000 species, accounting for 15% of the total number of 20%. The convention on international trade in endangered species of wild fauna and flora lists 640 endangered species in the world, China has 156 kinds, about a quarter of the total, many of which for medicinal species. Therefore, protection of endangered medicinal animal and plant resources is the trend of The Times, is also the needs of the development of Chinese medicine itself. Must change the development of Chinese medicine by direct use of resources for low cost production mode, measures should be taken to rational utilization and protection of traditional Chinese medicine resources.

Musk is indispensable to traditional Chinese medicine in fine-grained material varieties, and application in our country has 2000 years of history. Of mind-opening wake up function, invigorate the circulation of t2dm, acetanilide detumescence, used to first aid and treatment of common disease, frequently-occurring disease and intractable diseases. In 2003, our country will be musk deer as a level of protection, it is forbidden to hunt. In adult male musk deer, musk medicine source shortage, fake and inferior products flooding the market, seriously affected the proprietary Chinese medicine quality and medication safety.

So it is urgent to research and development of artificial musk. In the 1950 s, our country began to musk substitute. In 1975, the original YaoZhengJu presided at the national institutes of health research and development of the project, before and after nearly 20 years. Shanghai pharmaceutical group prescription medicines, deputy general manager of li3 qi2 told reporters, the journal of science and technology in "artificial musk" project, medicine undertook the raw sea can I or ii research task. Researchers refer to a large number of literature, through many times test, finally went through the process route, took out a phase I and phase ii clinical samples of all the required. The clinical experiments show that the effect of artificial and natural musk.

After Beijing, shandong and Shanghai research units work together, in 1994, approved by the ministry of health of artificial musk kind of new drugs for traditional Chinese medicine, and as a state secret varieties, "top secret" class management. In 2006, ministry of science and technology, and the state secrecy bureau will be the variety level classified national security technology. In order to solve some problems of the original process, improve quality, optimize process, reduce environmental treatment of pressure, "artificial musk industrialization of key components of synthesis and research" project in 2014 science and technology commission.

Traditional Chinese medicine (TCM) endangered medicinal materials can be artificial replacement?

Artificial musk and rare animal medicinal materials substitutes the success of the development of new drug of TCM. So, other herbs from endangered animals such as tiger, bear bile can research and development of artificial musk road?

Combine traditional Chinese and western medicine society of China, vice chairman, huashan hospital wen-jian wang professor wen-jian wang told reporters, the journal of science and technology can develop alternative products, it is to see the importance of the product, scarcity, 2 it is to input great manpower. Experts also said that China's national pharmacopoeia committee to wild animals and plants should be used for the source of traditional Chinese medicine safety, efficacy and quality controllable, reasonable dosage forms, wide application. Musk is indispensable, many of our traditional Chinese medicine (TCM) such as pills for nightfall, Ann palace bezoar, musk bao xin pills have musk composition, etc.

Research and development of artificial replacement of TCM variety needs a lot of human resources. Li3 qi2 stressed that the development of artificial musk is very difficult, time is long, investment is big, the project is led by the government, is the result of several drug companies cooperation.

Before and after artificial musk, research and development since 1975, nearly 20 years, by the Chinese academy of engineering, led by yu dq, institute of Chinese academy of medical sciences, medicine, traditional Chinese medicine (TCM) company of China, shandong macro economic hall pharmaceutical group co., LTD., Shanghai co., LTD and Beijing lian xin pharmaceutical co., LTD., etc. Units work together to complete.

Artificial substitute of endangered Chinese traditional medicine research needs vast investment and long cycle, artificial musk started first, followed by artificial cultivation bezoar and so on in vitro in China have also made significant progress, "innovation and development in the inheritance of TCM, we will adhere to follow the mechanism research, clinical research, the combination of process quality based on the research path, to speed up cultivating Chinese medicine varieties, rapid market competitiveness and further promote the modernization of traditional Chinese medicine (TCM) business development, leapfrog development." Li3 qi2 said.

Research and development of artificial musk model into traditional Chinese medicine modernization

Wen-jian wang said that at present there are two main directions for TCM modernization, one is artemisinin research path, namely the extraction of traditional Chinese medicine (TCM) chemical constituents, pharmacological animal model was established to confirm its pharmacological effects, the industrialization of research results; Another road is the replacement of traditional Chinese medicine (TCM) natural products, this is also part of the secondary development work. Study is the second path of artificial musk.

Li3 qi2, agreed that artificial musk project system study the main chemical compositions of the natural musk, created a substitute for active ingredients in natural musk, and large-scale production, is the success of the model for TCM modernization.