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In addition to anti-malaria, artemisinin value to be deep

2017年01月13日

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In addition to anti-malaria, artemisinin value to be deep

2017-01-13

Journal of Traditional Chinese Medicine

Access to the highest national science and technology award, 87-year-old Chinese Academy of Sciences Institute of life researcher and chief researcher Tu Yo Yo again into the public eye. From the Tu Yo Yo went to Sweden to receive Nobel Prize in Physiology or Medicine for more than a year, people's excitement and joy has not yet dispersed. This year, a series of honors did not disrupt the peaceful life of Tu Yo Yo, she is still I, diligently buried in the scientific research. Most worried about her, is to broaden the indications of artemisinin, artemisinin for more people to bring the Gospel.

Artemisia annua, Chinese medicine that the world attention

Malaria, folk known as "playing pendulum", in today's China has been hard to find. Most people's awareness of malaria comes from film and television works: from time to time to launch the disease, such as fire, sometimes falling like ice caves, trembling more than, endless pain. There have been countless deaths from malaria in the history of the war, military malaria caused by the outbreak of military failure have occurred. Malaria, the World Health Organization has been listed as one of the world's three major death diseases.

Since the beginning of this century, artemisinin began to dominate the treatment of malaria, suspended the pace of malaria invasion of human life. According to statistics, from 2000 to 2015, the incidence of malaria decreased by 38%, the number of people died of malaria decreased by 48%. WHO data show that about 240 million people in sub-Saharan Africa have benefited from artemisinin-based combination therapy since 2000, with about 1.5 million people avoiding death due to the treatment. Before the introduction and promotion of artemisinin, the world each year about 400 million people infected with malaria, at least 100 million people died of the disease.

It can be said that after the advent of artemisinin become a well-deserved "life-saving drugs."

"God drugs" come out, after twists and turns, is not easy. In the development process of antimalarial drugs, Tu Yo-yo led the task force to screen more than 2,000 Chinese herbal prescriptions, experienced 190 experiments failed. Research into the bottleneck, the Tu Yo Yo Chinese classics from the book "elbow emergency" to get inspiration, the first use of low-temperature ether extraction, this successful development of artemisinin, so that hundreds of millions of people worldwide benefit.

In recognition of the outstanding contribution of new antimalarial therapy, Sweden Karolinska Institute awarded Tu Yo Yo 2015 Nobel Prize in Physiology or Medicine. The world is listening to a Chinese story of Chinese scientists looking for antimalarial drugs from Chinese medicine. Tu Yo Yo to the world voice: Chinese medicine is a great treasure, artemisinin is a gift to the world of Chinese medicine.

Chinese Academy of Engineering, Dean of Chinese Academy of Sciences, accompanied by Tu Yo Yo Yo to Sweden to accept the award, and European medical exchanges so that he felt, from the treasure house of Chinese medicine to find inspiration, may be able to find a lot of world health problems crack the law. He hoped that Tu Yo Yo won the National Science and Technology Award to further promote the opportunity of Chinese medicine to the world, so that Chinese medicine produce more valuable results.

Words and deeds, artemisinin spirit of lead

Tu Yo Yo won the National Science and Technology Award, after the good news came, her research team members accepted the interview.

Chinese Academy of Traditional Chinese Medicine researcher Jiang Tingliang over the years has been a member of Tu Yo Yo research team, served as director of the Institute of Traditional Chinese Medicine, he was Tu Yo Yo year anti-malarial drug research direct leadership. Jiang Tingliang Tu Yo Yo admiration: "She has a strong sense of responsibility, to do one thing must be made."

January 21, 1969, Tu Yo Yo was appointed research team leader, involved in "523" task, for malaria research. Tu Yo Yo did not hesitate to take over the task assigned by the organization. Task force leader means responsibility and mission, but also means to pay and sacrifice. In order not to affect the work, Tu Yo Yo cruel to the eldest daughter Li Min to the nursery all care classes, the little daughter Li Jun returned to Ningbo home. Today, she remembered the matter still feel sorry for her daughter. But the face of special times of special tasks, in order to fulfill their mission, Tu Yo Yo make a difficult choice.

In the course of the study, the task group must be a large number of preparation of artemisinin ether extract. During the "Cultural Revolution" period, the pharmaceutical plant downtime, lack of equipment. Task Force "indigenous method", with seven large water tanks instead of conventional extraction containers. Ether and other organic solvents harmful to humans, due to lack of protective measures, many researchers have allergic reactions, Tu Yo Yo suffering from toxic hepatitis.

Tu Yo-yo's dedication to science is more than that. In July 1972, due to suspected side effects of animal experiments, drugs can not be directly used in clinical, Tu Yo Yo personally into battle, to the body test drugs. In August 1972, Tu Yo Yo carrying drugs rushed to the Hainan Changjiang epidemic area, in the heat of the summer heat, rush to find patients.

Tu Yo Yo's words and deeds are affecting the young researchers around. Her doctoral student Wang Manyuan said: "Tu teacher influence on me is imperceptible, from her, I learned to do research in the direction to find attention, we must firmly walk the road of scientific research." Her research assistant Yang Lan said: "Tu teacher inspired me, be sure to in-depth diving under a heart to do in order to become experts in this area." ZhangBoLi think, should vigorously promote the "artemisinin spirit." He will be "artemisinin spirit" summarized as: the whole country system, unity and cooperation; good at heritage, to be creative; hard work, willing to sacrifice.

After the award, artemisinin research will continue

January 14, 2016, the State Health and Family Planning Director Li Bin and the State Health and Family Planning Commission, deputy director of the State Administration of Traditional Chinese Medicine Wang Guoqiang came to Tu Yo Yo home condolences. Speaking of Nobel, Tu Yo humility and indifferent. Talking about the further study of artemisinin, Tu Yo Yo immediately become seriously focused. She said that artemisinin is a new substance, the next step should be thoroughly clear its mechanism, fully tap its potential.

Artemisinin more and more popular and widely used by the world, Tu Yo Yo but early attention to the abuse of artemisinin and the problem of drug resistance of Plasmodium. Some scientific literature and news reports referred to the emergence of artemisinin-resistant Plasmodium falciparum, Yo Yo is deeply worried. In a speech at the Karolinska Institute in Sweden, Tu Yo-yo called on the international community to standardize malaria treatment and stop drug abuse of artemisinin.

Tu Yo Yo never stop the in-depth study of artemisinin. In addition to the treatment of malaria, artemisinin for other parasitic diseases, immune system diseases have a certain effect, whether the impact on cancer is also being studied. In 1973, Tu Yo group successfully synthesized the first artemisinin derivative derivative - dihydroartemisinin, the substance can be used for the treatment of immune diseases, lupus erythematosus. In 2016, Dihydroartemisinin treatment of lupus erythematosus project through the State Food and Drug Administration approval, access to clinical trials of drug approval. Chinese Academy of Traditional Chinese Medicine Institute of Traditional Chinese Medicine and Kunming Pharmaceutical Group signed a joint clinical trials. According to Zhang Boxi, the existing clinical trial results show that artemisinin treatment of lupus erythematosus have a definite and stable effect on the treatment of discoid lupus erythematosus more than 90% of the effective treatment of systemic lupus erythematosus more than 80%.

In addition to artemisinin research, Tu Yo Yo is most concerned about is the next generation of growth. In addition to receiving travel expenses, she received her Nobel Prize in full donation to the work unit of China Academy of Traditional Chinese Medicine and his alma mater, Peking University, the establishment of incentive funds to support young people's scientific research and innovation. She sincerely hopes that young people can grow fast, can get more awards. She said: "China's scientific community will not be a Nobel Prize alone."

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In addition to anti-malaria, artemisinin value to be deep

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