Don't mistake should wear stability

China's traditional Chinese medicine reported

        Valium (diazepam ) is the most commonly used sedative hypnotic, sedative, hypnotic, anxiolytic effects, as well as central muscle relaxant, anticonvulsant, antitumor effect. The clinical commonly used in the treatment of various causes of insomnia, irritability, neurasthenia, infantile convulsion. However, at present as a result of job competition, come off sentry duty, education, and industry areas such as stress, abuse of stable population increasing. The expert reminds, in taking diazepam should pay attention to avoid the following drugs:

        Cimetidine cimetidine: because the enzyme inhibition effect, leading to stability in the liver metabolism slows, elevated plasma concentrations, pharmacological effects, adverse reactions such as drowsiness, dizziness, ataxia, increased significantly, the patients' daily work, especially in the driving, machine operator is very harmful, so the two medicine should not be used.

        Anti tuberculosis drug: due to the smoke guiding hydrazine can delay the diazepam metabolism running, so the use of isoniazid in patients, to reduce the amount of stability, in order to avoid the toxic and side effects; because of rifampicin could obviously increase the stability of the clearance rate, so it is needed to appropriately increase the amount of stability, but also because of stability can delay or reduced rifampicin in gastrointestinal absorption, reduced resistance to Mycobacterium tuberculosis curative effect, so the second season at intervals of 8 to 12 hours.

        Phenobarbital: two drugs often used in treatment of neurosis patients with insomnia. Combined use of two drugs can enhance the central inhibition, but older people prone to take leave of one's senses and illusion, and easy to produce drug resistance, should be reduced with caution.

        Thiazides: such as chlorpromazine, promethazine, perphenazine, when two kinds of injection drug use, can significantly enhance the central nervous system inhibition, episodic severe respiratory cycle accident, therefore we must strictly control the indications and the combined use of dose.

        Water soluble injection: because of stability does not dissolve in water, so the injection is and there is a large amount of propylene glycol and other organic solvent and made, and if water soluble injection such as sodium chloride, sodium bicarbonate, erythromycin, vitamin B6, ATP, procaine hydrochloride, atropine injection compatibility, will be due to solubility change and stability precipitation, produce turbidity or precipitation. So the stability not with water soluble injection compatibility, unfavorable also joined the infusion, or the use of water for injection dilution.

        In addition, the drink is not taking the stability. Because alcohol itself has paralysis nerve, nervous system reactivity decrease. If the drink and then taking a sedative hypnotic agent, synergistic effect, can aggravate this kind of drug toxicity, can be fatal poisoning. ( ZhuJianCai)