Three disorder medication time about

Feng Wenli Beijing Chaoyang Hospital director pharmacist pharmacy

        Hypertension, hyperlipidemia, hyperglycemia and other "three-high" patient increases day by day, every day there are many patients to consult this kind of problem. In fact, this class of drug taking time to have a rough rule.

        Hypertension blood pressure fluctuation in a day in a two peak appears -- at 9~ 11and 6 pm - 7, began to slow down, to morrow before dawn at2~ 3minimum. General antihypertensive agents in the medication after2~ 3 hours to reach maximum plasma concentration. Therefore, long-acting antihypertensive drugs, such as amlodipine, benazepril, losartan, usage once a day, in the morning 7 when to take advice, so that we can more effectively keep blood pressure stable. Some antihypertensive drugs should be taken with food, may increase the absorption of drug. Such as metoprolol, dining medication can make its bioavailability increase 40%. Some drugs preferably before meals1 hours, when fasting is taken, such as captopril, this is because the food can make its absorption is reduced from 30% to40%.

        Hyperlipidemia human plasma lipids comprised mainly of cholesterol, triglyceride. In vivo synthesis of cholesterol can be affected by an enzyme was studied, and the statin drugs can inhibit the activity of this enzyme, thereby blocking the synthesis of cholesterol. Due to cholesterol synthesis is increased with the night, so these drugs such as daily dosing once, then the best in evening takes.

        Hyperglycemia commonly used oral antidiabetic drugs acarbose in the mechanism of action is, accompanied by digestive food arrived at the upper parts of the small intestine, slow food glucose degradation and absorption into the blood speed, thereby reducing postprandial blood glucose level. Therefore, acarbose optimal take time to start eating the first export rice. But some drugs should be taking 30 minutes before a meal, can improve the efficacy of drugs, e.g. repaglinide.