The innovation of Chinese medicine should be introduced "early evaluation" strategy

China's traditional Chinese medicine to

        Since this year, a traditional Chinese medicine by policy "grace". The relevant state department of traditional Chinese medicine industry support action continuously, a series of positive policy shows that traditional Chinese medicine industry ushered in the environment is very favorable gold development era. Recently in the Hong Kong convention and exhibition center held the 11th international modernization of traditional Chinese medicine and health products exhibition and conference (ICMCM meeting), mining in traditional Chinese medicine "of treating disease before" the precautionary health care field potential, in view of the chronic disease, serious illness of the traditional Chinese medicine research and the innovation to become the hot topic.

        Deputy director of the state administration of traditional Chinese medicine LiDaNing in ICMCM meeting pointed out that the 21st century will be the medicine from basic medicine to health and medical development shall be given a heavier treatment to heavy prevention health care development, from in the treatment of pathogenic to overall regulation development. The transformation of medical model will lead the development of traditional Chinese medicine. Global heart disease, high blood pressure, cancer and other chronic diseases spread, for traditional Chinese medicine in the prevention health care field to provide a broad space for development.

        Cooperation mining potential

        In June this year issued by the traditional Chinese medicine career development "1025" plan "pointed out that the development of Chinese medicine should not only keep the special advantage and to actively by using modern technology. Through the knowledge innovation is unceasingly rich and the development of Chinese medicine theory system, through the technological innovation continuously improve TCM service capacity and technical level.

        Hong Kong university vice-chancellor professor noted that TanGuangHeng modern technology, traditional Chinese medicine is becoming the rise of important support strength, traditional Chinese medicine teaching, research and production are integration of modern technology.

        "Science based on observation and experiment to the material world and the systematic research of income knowledge. With more than four thousand years history in the traditional Chinese medicine, built on the discovery of herbal prescription, the innovation, listening, asking and cut observation and clinical test. And nearly several century western medicine, Chinese medicine compared to the pace of the seems to slow down. The good news is that, as long as we are willing to the introduction of advanced science and technology, such as proteomics, bioinformatics and clinical test, etc., traditional Chinese medicine can play its huge potential, become the pursuit of western medicine has' fusion sex", "system", "to test for this" "because of the person different" 'future medicine ".

        In fact, traditional Chinese medicine is not the scientific enterprise or an institution contribution can be realized. In TanGuangHeng view, traditional Chinese medicine has a system, and that he hoped to "can integrate different industry, the interrelations supervision department, research institutions, organizations, in order to" China meet the western "way to explore the cooperation of Chinese medicine scientific".

        Traditional Chinese medicine industry development and upgrade need cooperation, centralized resource advantage to form the joint effort.

        Since the 21st century, life science and biotechnology fields of rapid development and promote the drug research and medicine industry into a revolutionary change period. The completion of human genome project and the follow-up function genome, structure genome and protein has made great progress in the implementation of the plan, and accumulated a lot of data. But, how to from the mass of data to search for clues in the drug research, how to aim at the disease complex mechanism for drug action target become outstanding problems.

        "The problem of crack need to life science, mathematics, computer science and medical experts in the field of the effective cooperation and cross research." Shanghai university of traditional Chinese medicine principals, Shanghai, China institute of drug academic committee director ChenKaiXian academicians pointed out that the research and development of traditional Chinese medicine should also be closely combined with international drug research cutting-edge technology.

        Creating new path

        At present, our country drug research and medicine production is in from imitation to innovation is given priority to, mainly by manufacturing power toward innovation power transitions in the history period.

        At the meeting ChenKaiXian described in new drug research to move towards the independent innovation "three steps" strategy: from the 1990 s to the second half of 2010 years is accumulation stage, this one phase initially established a system of independent innovation framework and rudiment; From 2010 to 2015 is the rising stage, China's drug research and development innovation ability and level in international is expected to new drug development "the second square matrix" leading position, ahead of India, South Korea and other countries; From 2015 to 2020 is across the stage, China's new drug research and development ability and level for the or come close to the new drug research and development "the first square matrix", in the international advanced occupied a place among the ranks.

        To realize the dream of pharmaceutical power, and a long way to go, new drug research is still faced with great challenge. For the disease of heart head blood-vessel, neurodegenerative diseases, metabolic barrier disease, cancer and other pathogens is not clear, many factors lead to complex diseases and find effective drug treatment is still very difficult. The traditional, single channel and single target drug design idea, it is difficult to meet the intervention disease complex signal network purpose, difficult to be suitable for the system-related drug research.

        In addition, new drug research also faces a long life cycle, cost, risk high challenge. Many factors result in the most complex disease is a chronic disease, the more difficult, clinical research a greater risk of failure. Into a problem is often lead to drug development the main causes responsible for failure of late. According to statistics, because the pharmacokinetic properties caused by bad and toxicity of drug late failure rates as high as 60%, resulting in new drug research huge risks and losses.

        Therefore, ChenKaiXian puts forward, "early evaluation, early selection" should become the important strategy of drug development. He thought, new drug research and development not only to apply international drug research cutting-edge technology, but also strengthen the innovative drug transformation type research. In the transformation type of medical development under the new situation, new drug research to review development needs and connotation, rethink the breach of the new drug research and explore a new mode of new drug research. Basic research, drug development and medical practice between the three need to integrate.

        He also stressed that the pharmaceutical great nation to move towards the pharmaceutical powers in the process, our country should carry forward traditional Chinese medicine and natural medicine characteristics and advantages. "On the one hand, since the founding of our country in international biggish force in the new drug research, most of the traditional Chinese medicine and natural medicine is based on the research and development success. Such as antimalarial drug artesunate, treatment of ischemic stroke drugs styrene-butadiene phthalein and bicyclol, etc.; on the other hand, our country has the advantages of traditional Chinese medicine research and natural medicine study resources advantage. (WangXia)