"Old Chinese medicine" heart pill of musk in Shanghai scientific and technological progress first prize, drive and yellow pharmaceutical turnaround

(on September 24, 2012)

        Located in putuo district true south road 28000 square meters of factory, JiQiSheng is humming.

        More than 100 wearing a white workers are busy "stir" after 72 hours crushed (black) traditional Chinese medicine powder, and put them "pattern" into "king". "King" is Chinese traditional medicine heart pill of musk kernel, a "king" diameter is only 0.7 mm, for now, this process can only rely on done by hand.

        These through manual operation is made "king", after "the pill" - that is, on a package more powder, and ultimately into 0.32 cm in diameter of the little black grain, namely heart pill of musk unique particle pills type, this is can sold on the market of heart pill of musk. This medicine, a year to sell more than 4500 boxes, a box of 42 grain, aggregate and more than grain, it is in the factory that finished step by step.

        From the heart pill of musk listed in 1981 up to now, has passed 31 years, be so blindly "old Chinese medicine", unexpectedly last year won the Shanghai scientific and technological progress first prize, make a lot of people's congress levels. It has led the Shanghai and yellow pharmaceutical co., LTD. From a losing proposition to this year is expected to heart pill of musk sales of over 800 million yuan, "that's all rely on science and technology innovation. And yellow pharmaceutical general manager ZhouJunJie reiterated.

        Break traditional Chinese medicine "sure" awkward

        The birth of heart pill of musk, originated in Japan "JiuXinDan" in China's sell like hot cakes. In the 1970 s, Japan "JiuXinDan" from Hong Kong, guangzhou to enter the Chinese market, because of its good curative effect on coronary heart disease in the country, rush a boom, at that time was whirling $100 million, almost all over China, such as proprietary Chinese medicine export amount.

        "The research and development of the Chinese themselves JiuXinDan", this mission fell on the research and development of traditional Chinese medicine (TCM) was the strongest comprehensive ability of the original Shanghai Chinese medicine a factory (now Shanghai and yellow pharmaceutical) body, huashan hospital heart doctor DaiRuiHong song dynasty from a traditional "styrax pill" place get inspiration, QuWuCunJing, make sure the existing heart pill of musk seven gout drug formula and content.

        Traditional Chinese medicine and western medicine, western medicine most only a compound, in view of a target, and 7 taste traditional Chinese medicine means "complex", how many compounds, which compounds in which targets, are not clear. This is Chinese traditional medicine "disease", people including many doctors of traditional Chinese medicine to the understanding of the stay in "eat bad also eat the undead" level, some of the traditional Chinese medicine image compared to "shoot TV", the television suddenly didn't image, toward the back cover shoot slap, image recovery, but this recruit spirit when the hard.

        Take television this metaphor image place out the difference between the traditional Chinese and western medicine, western medicine pharmacology clear and definite target, pay attention to local; The doctor of traditional Chinese medicine claims the oneness between nature and culture, many targets, pay attention to comprehensive. To make traditional Chinese medicine presenting convincing, must take its composition, pharmacology, and mechanism of action research to clearly, including difficulty cans be imagined.

        2001 Shanghai set up its first joint venture in Shanghai and traditional Chinese medicine - yellow medicine, traditional Chinese medicine is a former Shanghai factory into and yellow pharmaceutical, the newly established joint venture company in see the heart pill of musk such good medicine, decision from the foundation of mechanism, KenXia this "hard bone" - find out and taste traditional Chinese medicine secret. Project from 2004 to 2012, at the municipal science and technology commission, under the support of research out of the heart pill of musk has promote therapeutic angiogenesis effect, commonly known as "drug bypass", and from the heart pill of musk isolated 95 kinds of pure compound, and determine its chemical structure, at the same time to clear up to the human body each compound which parts have why action.

        This is the innovation of traditional Chinese medicine (TCM) for the first time set up integrated chemical group of science research methods, this study from the material group study, genomics, metabolomics, proteomics Angle, all-round expounds the heart pill of musk mechanism of action.

        In the industrialization won the "rebirth"

        Use the method of science to explain the "nature and humanity" after the mechanism of action, and yellow pharmacy will heart pill of musk as the company's flagship product, began to industrialization road.

        Without advertising, according to the national advertising law, prescription drugs have already can't advertise; Without kickbacks - every grain of 0.66 yuan price, also to maintain the 80 s standards; Lost these relying on, heart pill of musk depend on what makes a enterprise industry profits, and maintained at an average annual rate of more than 30% of the strong growth?

        ZhouJunJie said, when we put the basic and clinical research from thin few pages into thick books, don't have to expend a what your breath, a professional trained doctors a look will understand this medicine what is good. Clinical doctors heart there is steelyard, doctors prefer to use curative effect definite, safe and cheap medicines, now the safety of the drug and the action mechanism are clear, doctors use very at ease.

        In the 80 s, heart pill of musk is money "medicine", but its popularity is limited to Shanghai and jiangsu and zhejiang provinces area, by the user's mouth from ear to ear; Now, heart pill of musk has covered the whole country all provinces, cities, and 2800 county hospital, this is Shanghai drug in the most widely national coverage of a product.

        Although a profit, but with the huge user group and good compliance, heart pill of musk sales rising year after year. It is and yellow pharmacy will heart pill of musk in secret explain and straighten out since the industrialization process, make the traditional Chinese medicine in greater depth and breadth in "rebirth", and thus won the 2011 Shanghai scientific and technological progress first prize.

        Start the internationalization of Chinese medicine road

        In 2010, and yellow pharmaceutical launched heart pill of musk of evidence-based medical research. The randomized, double-blind, multicenter, placebo controlled drug curative effect evaluation parallel of clinical research, by the national more than 100 home 3 armour hospital, 2700 cases of patients participation.

        Evidence-based medicine is the international judge a drug safety, effectiveness is most advanced, the most severe way, once the heart pill of musk is evidence-based medicine confirms in the treatment of chronic stability on patients with coronary artery disease sanative, then subsequently path of internationalization all right away.

        "No matter traditional Chinese medicine, western medicine, as long as I according to the international general method tell everybody the curative effect of this product is accepted, safety is controlled, it is enough to explain the problem." ZhouJunJie said.

        About heart pill of musk follow-up development continues, ZhouJunJie say they plan from 95 species composition extracted 4-5 kinds of the most active, have curative effect most composition, make a kind of new traditional Chinese medicine treatment of coronary heart disease (CHD) components.

        From the heart pill of musk body, ZhouJunJie the European multinational company for many years the Chinese people also learned that many since ancient times has been passed down from ancient prescriptions was indeed very valuable, the key is how to use modern scientific language to explain it, to explain clearly, the internationalization of Chinese medicine road games.

        At present, and yellow pharmaceutical is consisted of two varieties in foreign countries do phase ii clinical, four varieties in foreign countries do a phase of clinical, "Chinese traditional medicine industry real international market recognition, I think at least 5 years of way to go." ZhouJunJie said.