Vitamin C fructus forsythiae event security wake-up call again

Our reporter wang Dan

Source: health

        On June 18, the Hong Kong government news bulletin d C fructus forsythiae events, medicine experts interviewed by reporters, for Hong Kong in the way each treats the incident have expressed agreed: "on the one hand can alert the public, careful and reasonable use of Chinese and western medicine of compound preparation, on the other hand should also cause our reflection, to strengthen drug safety supervision, using aspects to further make improvements.

        Shall determine whether drugs had a similar problem with the same

        Was the cause of the incident last October, a 41-year-old female for rhabdomyolysis and hypokalemia, was sent to princess Margaret hospital in Hong Kong, potassium has been low ever since. In a follow-up visit in June this year, she told the doctor that he had used labeled "d C fructus forsythiae slice" for oral administration. Hong Kong hospital authority to assay the drug label and discovered that the product contains two is western medicine ingredient is disabled - and aminopyrine phenacetin. Shown in the product manuals, acetaminophen and vitamin C maleic acid chlorobenzene that sensitive but has not been turned out.

        "According to available information, now it seems should be classified as adverse drug events, rather than adverse drug reactions." Peking University third hospital clinical pharmacists Zhang Ting said, "the analysis of the incident, the first need to identify patients eligible drug".

        "Vitamin C fructus forsythiae pieces should contain honeysuckle, forsythia, platycodon grandiflorum and 10 taste traditional Chinese medicine (TCM), and vitamin C, maleic acid chlorobenzene that sensitive, acetaminophen 3 kinds of western medicine ingredients. But according to media reports, events of drug containing no specifications referred to specify the composition, and contains other uncharted compositions, this drug should be considered to be counterfeit." Zhang Ting said, drug regulatory departments shall supervise and inspect, identify whether drugs had a similar problem with the same.

        Mainland involved western medicine ingredient is still in use

        In mainland China also has Chinese and western medicine of compound preparation "vitamin C fructus forsythiae" security problems been notified. According to in September, 2010, 32 "adverse drug reactions information briefing", according to a January 1, 2004 to April 30, 2010, national adverse drug reaction monitoring center of case report databases "d C fructus forsythiae slices on the number of cases have been reported a total of 1885 cases, mainly involving the central and peripheral nervous system, digestive system, skin and affiliated organs, etc. Among them, the case for a total of 48 cases of serious adverse events, 2.55% of the total, no death reported cases.

        Navy general hospital pharmacy department professor sun, director of the original faithfully the truth, for the drug safety assessment can't light appeared many adverse reactions, more want to see how many people use the drugs, especially depends on the occurrence of severe adverse reactions.

        Loyal. Sun said, "phenacetin" and "amidopyrine" because can cause hemolytic anemia, grain sex leucocyte deficiency, such as serious adverse events, in the 1980 s has banned by most countries. In our country, although the two drugs can not as a separate, but still allows use in compound preparations.

        Reporter found, through the literature at present a variety of traditional Chinese medicine compound preparations, western medicine compound preparations are found in the above two kinds of ingredients, such as compound YanSuanJinGangWanAn slice, amidopyrine and phenacetin compound tablet, compound aspirin tablets, etc.

        The drugs will happen with the same adverse events reported incident or adverse reactions, loyal sun admitted that "say", needs to be monitored closely, such as problems in a timely manner to make intervention.

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