Provide pharmic research 4 kinds of anticancer drugs low prices can replace imported drugs 
 
 

Press time: 2015-04-30 13:46:31 source: big river - river 

    The reporter Dong Lin lu-feng wang xiao-min li wenping wedding photography
 
    "Motenlin", refers to the towering, steep cliff. For a dreams of pharmacists, he want to climb "motenlin" to the utmost, is the "original drugs", namely the original new drugs.
 
    China is a generic power, and after joining the WTO to begin to attach importance to the original drug, a branded drugs, often spend a decade of work, the giant of the hundreds of millions of dollars invested, Ming might after a storm comes a month. Worldwide, basic only dare to large multinational pharmaceutical companies, to develop.
 
    And pharmacists, zhengzhou, henan university vice-chancellor jun-biao chang, in this article it is bumpy road, has sunk penance for 23 years.
 
    From domestic to abroad and domestic, more than 8300 days and nights of the pursuit, he and his team out of the four kinds of with independent intellectual property rights of the original drug, the treatment of HIV/AIDS, cerebral infarction, liver cancer and hepatitis c drugs.
 
    This, is not only the original henan medicine "motenlin", is extremely rare in the country.
 
    A the seesaw battle of life and death
 
    "Now imported drugs is too expensive, many patients to eat." Xiao-bing Chen - oncologists
 
    On April 26th morning, China's famous poet Wang Guozhen died of liver cancer treatment is invalid.
 
    After April 21, working at henan province tumor hospital of xiao-bing Chen heard a bad news: the liver cancer of his classmates died.
 
    "In my early 40 s." As a tumor medicine experts, xiao-bing Chen is not the first time heard of death, however, every time I heard such news, his heart will tremble.
 
    Very little "in the treatment of liver cancer drug, or poor effect, high toxicity, or the price is very high, there is a kind of imported drugs effect is good, but fifty thousand yuan a month, few families can afford." Xiao-bing Chen said.
 
    In fact, in many imported drugs, the drug is not a "one high" alone.
 
    Earlier this year, once the country's "the first person of anticancer drugs act as purchasing agency abroad", the core of the case is also expensive imported drugs - gleevec.
 
    "I could not live without gleevec now, but use the imported drugs, it is too difficult." In march of this year, free of litigant Liu Yong in an interview with the river news reporter.
 
    This kind of struggle in almost every critically ill patients, more or less.
 
    Xiao-bing Chen as: the seesaw battle of life and death. But, unfortunately, a lot of times, the seesaw battle, lose is the people, "now imported drugs is too expensive, many patients to eat".
 
    For this kind of predicament, pharmacists in henan province, zhengzhou university vice-chancellor jun-biao chang is clear.
 
    "For it is the original drug, so investment is high, the cost, plus is imported drugs, additional cost will be higher." For this kind of situation, jun-biao chang believes that true to cut drug prices, still depends on our, no second choice.
 
    Have, according to foreign research and development a new drug, average period more than 10 years, invested more than $1 billion, and in the pharmaceutical industry in China, the original medicine accounted for only about 5%, the remaining 95% for generic drugs.
 
    "We're doing animal experiments of liver cancer drugs once listed, can replace imported drugs. By contrast, the existing imported drugs is the price of the new drug of dozens of times." In addition, more make jun-biao chang and his team, their resistance to liver cancer drug efficacy is better, because with - targeting property.
 
    Let the price down, just can make more patients benefit in the process of treatment.
 
    Targeted drugs, can choose lesions
 
    Cancer cells can be a precise, less damage to normal cells, it is targeting - jun-biao chang
 
    In his lab, jun-biao chang: now the biggest trouble is that a lot of drugs into the body, it can't distinguish good or bad, good and bad cells together.
 
    After repeated experiments and research, surprised to find that he and his team, they invented the liver cancer drug amino phosphate - 5 - floxuridine can fire of precision of cancer cells, and less damage to normal cells, this is called targeting.
 
    Why is that?
 
    This is because they in the liver cells found a "password", the password is enzyme, P450 1 b1. Studies have confirmed that P450 1 b1 is lower expression in normal cells, is highly expressed in liver cancer cells. And that of amine phosphate - 5 - floxuridine provides convenient selectively kill cancer cells.
 
    Worry about reporters listen to not understand, jun-biao chang and he made an image of the metaphor.
 
    This medicine is like a small car carry cargo, entered the good cells, due to the enzyme P450 1 b1 is lower expression, drugs don't work, that is to say, the car can't unload the goods, then the whole out of cells. Into cancer cells, the enzyme P450 1 b1 is highly expressed, at this point, the enzyme is compared to a worker, it will put the cargo unloaded, and then unloaded empty car out of cells, into the extracorporeal circulation.
 
    At present, the laboratory has completed its pharmacodynamics, animal acute toxicity, subacute toxicity test, is preparing to do animal poisoning experiment.
 
    Jun-biao chang is expected, if all goes well, the medicine next year will enter the clinical.
 
    Let jun-biao chang and the satisfaction of the team, in the process of the existing research, people found the P450 1 b1 is highly expressed in many cancer cells, so this suggests that in the future, he can use the "targeted" to breast cancer, prostate cancer, colorectal cancer, gastric cancer, "is now developed HCV drugs is also a target of drugs, and liver cancer medicine".
 
    Find the "treasure" in celery, research and development of medicine
 
    Your food is your medicine - Hippocrates the ancestors of western medicine
 
    On April 22, jun-biao chang also received a phone call.
 
    The phone calling from heilongjiang, separated by a meter far, journalists can hear a voice says: "professor chang, embarrassed to disturb you, my name is zhou, my father is a cerebral infarction and just want to ask what time you study the cerebral infarction drug production?"
 
    Every day, the telephone, jun-biao chang to receive several, among them, there are a lot of people, he did not know, they are a preacher found his phone.
 
    What's more, there are patients directly "wall" he went to his office door.
 
    On April 13, on Monday, the morning go to work of jun-biao chang, he saw in his office door, a man in his 50 s to lean on the wall is waiting for him.
 
    Saw jun-biao chang, man limped meet up: "you are always the principal, I come to school a couple of times, is to want to see you, ask you what time can buy that cerebral infarction was medicine."
 
    And all this, because on November 25, last year, he and the team's another original drugs - cerebral infarction drug patents for technology transfer, patent transfer fee of 45 million yuan technology to create the zhengzhou university of monomial achievement transfer record.
 
    Speaking of the cerebral infarction medicine, many people will feel curious about its origin, because, one of the main ingredients in the medicine is extracted from celery.
 
    How did jun-biao chang thought of from the celery in Indian arrowheads?
 
    The ancient greeks Hippocrates was known as the "western medicine", he once said: "your food is your medicine." Concept of Chinese medicine, the more common cognitive "medicine food homology".
 
    The fusion of Chinese and western medicine nourishing, gave jun-biao chang crackle of inspiration.
 
    "Celery itself fall blood pressure, is good for cerebrovascular." Jun-biao chang said. In the end, he led more than 50 people, studying 13 years, use of the active ingredient extracted from celery, structure optimization, production has become the new cerebral infarction medicine - the broad with sodium injection. And that 50 people, the oldest is 92 years old.
 
    At present this medicine has been declared to the state food and drug supervision and administration bureau of clinical, waiting to enter clinical, "we have already applied to the national new drug fast review, but even so, the approval documents of clinical batch down the fastest also get half a year." Say this sentence, jun-biao chang seem a bit worried.
 
    The first original challenge from AIDS drugs research and development
 
    "Chinese people and foreigners than stupid, I must struggle for himself." - jun-biao chang
 
    High and new technology development zone, zhengzhou city, 100 science avenue.
 
    A building is no label within the White House is located in zhengzhou university quietly tian jian road southeast corner avenue and mooring. 3 floor of the room, the sunset glow refracted through didn't keep out of the window to the wall, in dappled light, wall which all quiet and mysterious molecule structure of the system. It is the owner of the - jun-biao chang.
 
    In his words, there is no complex instruments, chemical experiment is do in these simple bottles. Scientific research is no mystery, actually very simple, is ideas and find the right way to solve the problem.
 
    Such laboratory, jun-biao chang and his team in a few, but they conquer the target once established, are difficult to change again.
 
    Jun-biao chang is henan huaxian county enjoys.
 
    In 1982, jun-biao chang from henan huaxian county enjoys a rural admit to the chemistry department of henan university. Four years later, he graduated from the university, although you can arbitrarily pick "distribution unit", but he gave up, had chosen to continue to learn, admitted to the master graduate student.
 
    And that, not a destination.
 
    Jun-biao chang then went on to Beijing union medical university institute of medicine study, take the doctor of science degree, and to the university of Georgia college of pharmacy, and become a postdoc.
 
    All the way to study, jun-biao chang of a growing interest in drug development.
 
    Little in our country, the original drug, jun-biao chang swear, in the original drugs had some successes, "the Chinese people and foreigners than stupid, to struggle for myself, too".
 
    But the path to the original medicine "motenlin", how tortuous. Jun-biao chang and his team, day after day, night after night, non-stop to endeavour.
 
    2000 years or so, they will look first to put on a cure AIDS medicine, "in the treatment of AIDS drugs can't eradicate the AIDS virus (HIV) in the body, and need long time taking and resistance, side effects."
 
    11 years later, they first study successfully to the end of AIDS drugs, az, a phase of clinical trial has been basically end.
 
    "That's too bad." The mention of az, responsible for the management of the drug clinical trial of tianjin crown frequently company iv constantly praise. Issue, he said, to participate in clinical trials in patients with about 50 people, all consistent feedback as a result, the drug curative effect is very good, very low side effects and dosage are rare.
 
    "Dose is a small percentage of AIDS drugs in the world, but the effect has reached the international advanced level of AIDS drugs." Iv said.
 
    Climbing "motenlin" narrow mountain path, the instant a line of skylight, faint and flowing water, flowers county.
 
    On December 16, 2011, anti-aids drugs, az to transfer 40 million yuan price of patent to a company in Beijing.
 
    "Right now in phase ii and phase iii trial".
 
    Leave the two kinds of new drugs in henan became his desire
 
    Research and development of new drugs is to measure a region an important symbol of comprehensive strength of science and technology, henan province pharmacological society of qing-duan wang
 
    So far, jun-biao chang and his team have developed four types of drugs: AIDS drugs have been used in clinical, drug for the treatment of cerebral infarction has, according to the clinical treatment of liver cancer, drug for the treatment of hepatitis c is doing before clinical trials.
 
    "AIDS drugs and cerebral infarction drug patents already transfer, the rest of the liver cancer and hepatitis c drug, was not prepared to transfer to other provinces." Jun-biao chang said, these two kinds of medicine have to stay in henan.
 
    Henan after receiving this message a longtime jun-biao chang research process of intellectual property rights experts, Mr Li was very excited, also very moved.
 
    "Can't be sold, all have to stay in henan. Henan is a big agricultural province, the kinds of how much food to buy a box of medicine? And these drugs, can become a new brand in henan." In li opinion, a brand can support the development of an industry, an industry can support a regional development. America, for example, ford, general motors and Chrysler big three auto brand to support the "motor city, Detroit, Boeing to prop up in Seattle, the medicine frequently handsome target, can completely in the development of henan plays an extremely important role.
 
    "Henan before the drug research and development has been no big team, but jun-biao chang lead the team to henan set up a very good development platform." In henan province pharmacological society of qing-duan wang's eyes, new drug research and development is one of the most complex human intelligence activity, is also a measure of a region an important symbol of comprehensive strength of science and technology, our province to get development, must be in new drug research and development ability has been increased greatly.
 
    As a native of henan, jun-biao chang in henan have a is really emotional and responsibility, he wants to use science and technology innovation bring up more well-being.
 
    He hopes that by themselves and the efforts of the team, on the one hand, the rapid increase of henan province and even the domestic areas of scientific research innovation ability, on the one hand, can also be on the high life-saving medicine for thousands of patients burden.
 
    Who sun simiao said in "the daughter s", "between heaven and earth, only for you. People are expensive, is life". And developed a new drug, is "of a party, the DE more than the".
 
    In march this year, when "the first person of anticancer drugs act as purchasing agency abroad" Liu Yong case throughout the great river north and south, jun-biao chang pour out more intense time sense of urgency, "hope this four kinds of medicine to put into production, because the earlier put into production, the sooner people will benefit."
 
    As a 211 university vice-chancellor, jun-biao chang is responsible for some administrative work. The busy work, his favorite time in a lab. In the week, he longs for most is Saturday and Sunday, because these two days he can fully and the team together, in the experiment.
 
    Every minute counts, only because doctors without borders, the tzu chi relief.