Veterinary drug research and development in China: development and reasonable use

The 2015-12-30 08:51

Source: animal science and technology information

A, veterinary medicine industry, present situation and the problems we are facing

Too much production enterprises, by the end of 2013, 1804 national veterinary medicine enterprises. Medicine enterprises, 1727, 77 biological products enterprises. Gross output value of 43.75 billion yuan, of which 43.75 billion yuan medicine corporations, accounted for about 70%; Of crude drugs, 10.456 billion enterprises accounted for about 30%. From personnel of course of 165000. Nearly six annual 13.64% annual growth rate of veterinary drug industry is in a new transition period, facing the laws and regulations, administrative management, market competition, and food safety requirements such as multiple pressures, also facing the adjustment, as a big important opportunities.

1. Management: due to the attention of the government on food safety, have common administrative level rise to law. Punishment for veterinary drug violations: a fine - a lifetime ban - sentence.

2. Large compound has do not conform to the requirements of the management to improve curative effect, need a new way: preparation technology, process, raw material, the use of compatibility, etc.

3. Serious product homogeneity, a single document number more than 800 varieties, has 16.

4. Product variety is overmuch, conveniently small, lack of brand products, brand awareness is not strong.

5. Disable some drugs, market lacks good alternatives

Antiviral: amantadine and ribavirin, etc

Antimicrobials, furan, metronidazole, etc., some people use antibiotic, such as the effect of class.

Glucocorticoid non-steroidal anti-inflammatory drugs: such as analgin, fluorine solzhenitsyn (is compound), but the market demand is big, gap is serious.

6. Veterinary drug residue monitoring is becoming more and more strict, Hugh medicine period will be implemented strictly.

7. Drug application strictly, make many antibacterial drugs, etc. The application scope of narrow. Such as animal aspects: madurai limit for chicken, olaquindox limited to below 35 kg pig. Laying hens lay eggs period disabled, lactation disabled, etc.

8. The raw material drug slow progress: innovation of veterinary drug products, a kind of new veterinary drugs less (nearly five years less than 4). 1987-2009, China had approved about 210 kinds of new veterinary chemicals, and develop the type of structure of veterinary drugs only acetyl methyl ketene ketoneses sinensis and 2 species, accounting for 1% of new chemicals, 95% in the approval of new drugs is three kinds of medicine (that is, the generic drugs, veterinary medicine preparation abroad or compound preparations) in the 2005 edition of veterinary drug standard (medicine part), contains about 430 kinds of products, including veterinary decongestion (raw materials and preparations) only 51 species, accounting for 12% of the contains varieties; Veterinary drug companies are mostly small and medium-sized manufacturing enterprises, the lack of new product project ability; Product development strategic focus; The weakness of research, research and development ability; R&d spending is low (7%), the low added value, the transformation is difficult. Veterinary drug innovation ability is low, mainly for the generic veterinary drug products abroad and will people use drugs instead of veterinary drugs. Especially API production and research and development need to strengthen.

Second, the development direction of veterinary drugs

1 standardization development

Veterinary medicine industry in our country has developed rapidly, but still in its infancy. Since 1999 certification, at present our country by the ministry of agriculture GMP certification of the veterinary drug production enterprise about 2000. There are still not completely in accordance with the GMP regulations production, not strictly enforce the national quality standard, veterinary medicine of the vast market, but demand is high, standardized development is the trend of The Times.

2. Mergers and acquisitions, restructuring, integration moved closer

Veterinary drug industry regulatory strength increasing, and constantly standard veterinary drug industry market, as well as the policy tilt, resource advantage enterprises to the central, appear polarization phenomenon. Some disadvantages of enterprises be advantage enterprise merger, reorganization or consolidation.

3. The therapeutic drugs to prevent health development

Food safety problem more and more attention, livestock and poultry products export restrictions more and more strict, the degree of intensive aquaculture in China more and more high, most of the major diseases of livestock and poultry are disappear or get a better control, especially the application of antibiotic drug therapeutic drugs reducing year by year.

4. The brand development has a long way

The veterinary drug product homogeneity serious, lack of particular brand, brand is the embodiment of the corporate credibility and image, is the intangible asset of an enterprise, taking the path of the brand, pay attention to product innovation and intellectual property, is the key of runoff in the future market.

5. The development of new veterinary drugs will become the core of enterprise development

Has a long-term strategic planning, with independent intellectual property products, research and development strength strong enterprise development will become the mainstream of veterinary drug industry, the development of new veterinary drugs will become the enterprise competition is the core of the future.

Veterinary medicine new medicine and new dosage forms; Using liposome, nanoparticles or micro capsule, microspheres, emulsion, transdermal drug delivery system and other modern technology, development of long-acting sustained-release preparations, controlled-release, dash agent, spray aerosol, targeted agents, etc. New animal dedicated antimicrobials, high efficiency, low toxicity and low residue; Develop new biotech drugs Such as microbial agents, genetic engineering vaccine. Research and development of traditional Chinese medicine mainly from a single component, Chinese medicine effective parts, combination of Chinese and western.

3. Coping strategies

Strengthen independent innovation, research and development of animal decongestion: innovation of veterinary drug research is a high and new technology of system engineering, need pharmaceutical chemistry, analytical chemistry, biology, biochemistry, molecular biology, pharmacology, veterinary medicine, computer and other multi-disciplinary collaboration research. Imitation is given priority to, gen imitation combination, created primarily, short term rapid implementation, research and development of a variety of veterinary medicine new medicine (new apis, the new formula, new dosage form) mining resources treasure, research and development with independent intellectual property rights of veterinary drugs in veterinary medicine. Strengthen in veterinary medicine and veterinary medicine of Chinese and western combination of research and development of new veterinary drugs and development with independent intellectual property rights in our country the new formula, to carry out the listed drug synthesis of new technology research, improve product market competition.

Solid dispersions drug molecules, colloidal and microcrystalline or amorphous state, dispersed in carrier material to form drug carrier - solid dispersion system; High dispersion characteristics of the drug, shadowing effect, slow hydrolysis and oxidation; Cover up bad smell and excitant, solid liquid drug; Application to increase rate of drug dissolution and difficult solubility and slow controlled release preparations, difficult to improve F preparation soluble carrier, controlled drug release in the small intestine; Development of solid dispersions products: for m star solid dispersions, um, the effect of solid dispersion premix, solid dispersion premix compound amoxicillin, fluorine benzene nicol, solid dispersion;

4. The reasonable combination of science

The combination principle: for symptomatic treatment principle; The important principle of medication is urgent for its standard, slow is put to the book. And symptoms.

5. Pay attention to the biological safety

Strengthening breeding environment health management: to adapt to the by - prevention, cure by the transition of the anti - health care (a) to reduce unnecessary unreasonable drug use health care drugs, improve immune function of strengthen research application, aiming to reduce disease.