According to the ratio measurement, "value" or innovation?

Time: the 2016-01-11

 source: China's traditional Chinese medicine the author: yong-guang jiang

"Prescription is not the secret lies in the amount of", more than a medicine of traditional Chinese medicine compound, dosage of Chinese medicine has the branch of absolute quantity and relative quantity. Absolute, refers to the actual amount, how much is the gram is how many grams of; Relative amounts, refers to the ratio of the total dose of each drug prescriptions, such as the whole party a total of 100 grams, the drug dosage of a medicine for 10 grams, namely content of quantity of one over ten. Because of Chinese traditional medicine have different types, absolute and effectiveness is not corresponding, such as 100 grams of gypsum and 100 grams of asarum no comparable. Relative amounts, both one to one, is more often a one-to-many relationship of dose, reaction to medicine or the status of a medicine in prescriptions, and thus can be side effects of proportion of each medicine in the perspective. Which involves the effects of different drugs standard difference, situation is very complicated. In addition to the traditional Chinese medicine medicinal broth, any dosage forms of traditional Chinese medicine compound is involved in these issues.

Because of this, the study of traditional Chinese medicine dosage difficulty is very great, still rely on experience of traditional Chinese medicine in the exploration and accumulation. Of traditional Chinese medicine is not in the Swiss, however, between intentionally or unintentionally, and found a don't in some way. May not completely reasonable, but the clinical use of feasible, is worth reference and research.

Swiss formulas dose rate

Switzerland's exemption decoct Chinese traditional medicine has two kinds of dosage forms, one is our domestic visible granules; Another agent, namely single taste traditional Chinese medicine (TCM) aqueous solution, actually this kind of dry aqueous solution with vehicle becomes granules. The author is the most commonly used agent, subjectively consider two things: one is than granules, water less a drying process, may be able to better retain some ingredients of traditional Chinese medicine, Second, agent without excipient, medicinal composition is relatively pure, taste better.

The two formulations on the dose calculation and requirement is the same principle, namely the ratio of dose. Our domestic free tisanes are according to different doses of the packaging, is the absolute dose. Such as radix bupleuri, 3 g, 9 g, 15 grams of different specifications, such as packaging. Such as physicians with 6 grams, can send two 3 g; With 12 g, respectively with a 3 g, 9 g and so on. With the traditional one of exactly the same measurement. Swiss tisanes USES is free ratio measurement method, this almost every domestic TCM doctor guessing, don't know is how to calculate. Because the factory just tell you, you to the traditional Chinese medicine prescribed line, recipe is no problem. But confusing is, as long as the patients take time (1 or 2 weeks, etc.) and dose (number of daily and grams), the same whether you drove a six herbs, or 12 herbs, or herbs, or significantly adjust the dose of the same prescription, patients received are the same a pack or a bottle of medicine.

To find out how the dose calculation, the author conducted a survey to manufacturer, ask each other face to face, also on hand to take a look at the process of measurement formula. When thoughts turn around, is actually very simple. "Blank SLATE" of foreigners in Chinese medicine theory, in the treatment of traditional Chinese medicine (TCM) train of thought was also a lot less. They put a total dose of prescription of traditional Chinese medicine as a 100, no matter how many, how much dose of each ingredients ingredients, are calculated according to the ratio of the total in the prescription, and then determined according to the dose every herbs specific is how much. But the granules and water, is slightly different.

Granules, what dose is required for a prescription, include several times a day, how many grams every time, take a few days. As cassia twig monkshood soup: 12 grams of cassia twig, root of herbaceous peony 12 grams, the ginger 9 g, 12 g, big jujube main licorice 9 grams, 6 grams, lateral root of aconite asked patients take 3 times a day, every time 3 g, a total of 7 days. So, the first step, calculation of single herbs in the prescription dose rate, cassia twig, radix paeoniae alba, 20% and 20%, 20%, 20% of ginger, jujube, main licorice 20%, 10% of lateral root.

The second step, according to the total dose calculation formula, 3 g * 3 * 7 = 63 g. Each herbs in the prescription dose calculation and can be calculated by the 63 grams of a few percent.

Third step, calculate each herbs formula dosage, cassia twig 12.6 grams, radix paeoniae alba 12.6 grams, 12.6 grams of ginger, jujube, main licorice 9.45 grams, 9.45 grams of 6.3 agent, lateral root of aconite and granules, doses not in accordance with the "g" in the operation, and calculated on ml, but of the same dose conversion method and the granules. Physicians are still using traditional one way a prescription, just need to specify two points: first, write need ml number, a total of three kinds of specifications, the 50 ml, 100 ml and 200 ml, according to the adults usually dose respectively corresponding to the number of for 5 days, 10 and 20 days; Second, write daily use times and spoon number (with a small spoon, medicine distribution a spoonful of about 1.5 ml), so the number of days the above bottle of medicine will change with different dose.

Swiss adopt this kind of measurement method for a reason, there is a basis. There are two reasons, one is standardization, in the consciousness of the foreigner, not standardization is not science, is not good. 2 it is commercial, standardization and finished product are for commercial service. Speak simple point, that is, on the premise of guarantee the stability of product performance, quality, establish a unified product specification and application of the way, this is conducive to mass industrial production, and easy to use and accept for market (patients), in order to realize the broader market opened up, win more profits. In Switzerland, therefore, dosage of Chinese medicine, according to the ratio measurement is out of necessity.

Dose rate is not a "renegade"

Swiss exemption decoct Chinese traditional medicine, however, measurement method and not completely deviate from the measuring principle of Chinese traditional medicine, has its rationality, also has inherited genes. Because, in the prescription dose exist ratio relations, and this is the most important, compatibility of the formulas is also the most hidden rules and laws. Typhoid fever there is a lot of ingredients in the same, just adjust the dosage and effect change and attending formula, such as cassia twig decoction, cassia twig and laurel, cassia twig and Que soup, soup and small bearing gas soup, three things decoction, magnolia bark when big and so on. Later children are scattered, angelica blood tonic soup, yupinfeng powder, and the drugs are clearly in the dosage ratio. Related to modern research also proved that the dosage ratio, prescription sex effect difference, even have significant differences.

Based on ten years a large number of clinical application, the author confirmed that amount is greatly less than traditional Chinese medicine medicinal broth of free tisanes are effective, dose rate has its practical effectiveness and does not conflict with the traditional absolute dose rules, can be added a compatibility of clinical thinking dimension.

, of course, the author is not to deny absolute dose and its importance, but dosage is not big, Chinese medicine, dare to use large dose is the medical degree. A single herbs prescriptions, how many and the dosage of the overall compatibility of the dose of the formulas is two dimensions, while the former is based on the latter in terms of size. At the same time, the concept and features of the latter can reflect Chinese medicine cure. Because, dose again big also has a limit, for example, a prescription with 200 herbs, and other drugs, the drug quality, and the medicinal properties of lateral root of aconite water solubility, and patients had taken much, are the need to discuss.

Dose rate of form a complete set of rules

Domestic tisanes free there is no special regulation on dosage, vendor just told doctors, avoid tisanes as thickening agent, the prescription according to the dosage, reduce some soup can. Some manufacturer in pharmaceutical packaging printed on each bag is equivalent to "several grams" of Chinese medicine yinpian, but what is several didn't say, is very casual, the lack of a strict specification. The application of doctors and patients is bad, will affect curative effect, of course, also can affect sales and promotion. Because of that, at least let a person feel is not normal.

Swiss sell tisanes free vendor will provide the formula method and the application rules, both the detailed text material, its website can query and download. In addition to the front about tisanes free formula method, and some rules of form a complete set, or can be used for medical and domestic manufacturers.

Granules and water quantity requirement is different. Agent, front spoke of the "medicine spoon" with a spoonful of about 1.5 ml, no more than 15 ml per day. But this quantity is associated with prescription number of ingredients, less ingredients, will also have to reduce the dose, such as 1 ~ 2 herbs prescriptions, daily in 3 ml; 9 ~ 12 herbs prescriptions, at about 6 ml daily. Specific share very thin, not list one by one here. Clinically, we as a reference, usually slightly higher. But there is the standard dosage, more easily also some specification.

Granules, good quantity and dosage of two doses of requirements. A. prescription doses, 4 ~ 20 grams, daily minimum 4 ~ 6 g; The average amount of 8 ~ 12 g; The highest quantity: 12 ~ 20 grams. B. single dosage, 0.5 ~ 2.0 g daily; Minimum, 0.5 grams, equivalent to the original crude drugs for 3 ~ 5 g; Average, 0.8 ~ 1 g, equivalent to the original crude drugs 9 ~ 12 g; The highest amount, 2 g, equivalent to the original 18 ~ 22 grams of crude drug.

Children dose have special requirements, not only reduced by kilogram and according to the different measurement methods of the surface area is reduced, also points emergency capacity, as well as general and conservative three scenarios dosage range is put forward.

That opened in addition, some toxic or medicinal fierce drugs, such as lateral root, pinellia, radix aconiti, centipede, ephedra, rhubarb, evodia rutaecarpa, etc., have a daily dose limit requirements, must abide by when prescription. Such as the amount of these drugs in excess of that specified, formulation system will alarm, the manufacturer also can telephone contact the clinic, your attention, and modify the dosage.