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Artesunate study highlights the value of the system of scientific research

2011年09月21日

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Artesunate study highlights the value

of the system of scientific research

 

China's traditional Chinese medicine reported

 

YouYou researcher for slaughter in research and treatment of malaria drug artesunate has made great contributions in get lasker award, has become the world's medical community of a news, and academic circles in China medical cause tremendous echo. Although the award recognition of the carcasses of YouYou decades ago is research, but to today's Chinese medicine research still has important instruction meaning.

Traditional Chinese medicine research topic selection to close to social needs

We often say that scientific research to "heroic", "day" is the social needs. To improve the health level of the Chinese people, dredging service is the traditional Chinese medicine research "day", to improve the health level of the world's people, preventing and treating illnesses are more traditional Chinese medicine research wide "day". This is both the three traditional Chinese medicine, also be the basic attributes of medical research and fundamental purpose.

At present, many awkward questions in front, such as medical resistant bacteria infection control, malignant tumor of the high degree of the treatment of infectious diseases, new hair the prevention and treatment of the lifestyle changes in various metabolic disease's treatment and so on, Chinese medicine research should not only to join, and to reveal the strength. The Chinese medicine research, it is an inevitable challenge, but also a rare historic opportunity.

Traditional Chinese medicine (TCM) is a great treasure, as long as we concentrated study, serious, inheritance of excavation, exploring the innovation improve, it can make new great discovery and invention. This, YouYou slaughter decades ago are done.

Artesunate study highlights the study of traditional Chinese medicine scientific spirit. For reference, the application of modern science and technology is the theory and method of traditional Chinese medical science research modernization, industrialization and internationalization of a solid foundation. Traditional Chinese medicine research to follow the general rule of scientific research, applied science research method, but also must be from the reality of medical research, for the traditional Chinese medicine research special laws, the study of traditional Chinese medicine to solve specific problems.

YouYou slaughter studied medicine, early graduated from Beijing university medical school, and after graduation, some proposals in Chinese medicine research and took part in the "national in the third phase, leaving study traditional Chinese medicine and western medicine class", the system to study the knowledge of TCM. Her achievements benefit from solid grounding and tireless pharmaceutical study, spirit. According to the report, the leadership of the team YouYou carcasses from retrieval, sorting the Chinese medical books, and began to visit old literature of traditional Chinese medicine, 2000 DuoGe screening of Chinese herbal medicine, and party by the "cubits backup nasty party" inspiration, found only the effectiveness of the extract.

But the conventional extraction is not ideal, and after the repeated the experiment, the ether extract, low temperature after 190 DuoCi failures, and finally got to rat engineer, monkey destiny, the inhibition rate to the 100% of plasmodium falciparum artemisia extract. And then again to only the neutral and acid extract ingredients do thorough research, found that neutral part antimalarial titer high and low toxicity, the monkey experiment, engineer get satisfied results. In animal experiments, and on the basis of, in 1972 and 1973 in hainan ChangJiang region will extract only for malaria treatment, efficacy than antimalarial chloroquine. To 1978, a total of 2099 cases, and they all got the treatment of clinical cure.

Traditional Chinese medicine research need course cross, big team of tackling key problems

Our country large-scale antimalarial drugs to research in global malaria is hard to control of the late 1960 s, in that special period, scientific research environment is not good. But chairman MAO and premier zhou, joint research and development antimalarial ordered new drugs, held in Beijing "national malaria control research through the meeting, into formed all over the country DuoGe unit, including 60 in western medicine, Chinese traditional medicine research of more than 500 scientific research personnel to the new drug research, the antimalarial slaughter YouYou is one among them. For the strength of all, multidisciplinary conquer antimalarial drug research achievements, the research achievement, artesunate Chinese research antimalarial drug international status.

40 DuoNian past, either as a traditional Chinese medicine research external conditions of Chinese politics, economy, culture, science and technology, the international status, or as the inner strength, Chinese medicine research have improved by leaps and bounds of ascension that is obvious. But, concentrated much discipline, high level researchers "corps combat" division, is still applied science collaborative research (including traditional Chinese medicine research, science and technology, problems to solve make big social contribution of the necessary way.

The internationalization of Chinese medicine research is the only way for the development of traditional Chinese medicine. "Only national ability is the world", this sentence strictly speaking not rigorous, complete statement should be "only by the world to admit that the, national ability is the world". The statement read some clumsy, but accurate. To a scientific discovery, a scientific invention of the evaluation of the value, it is to see its universality and application scope. Worldwide general significance and can widely used, and the scientific value is great.

Chinese medicine control the universality of the disease in the world are getting more and more people's attention. Traditional Chinese medicine in the service of science and technology of China, revealing of hard power and soft power Chinese culture. But to make the world more and more people know the treasure of Chinese medicine, there is still a lot more work to do. Traditional Chinese medicine scientific research is concerned, to join the international science and technology research, it is to let the world circulation in the academic circle, recognition and evaluation found that Chinese medicine research results of the basic conditions.

In march of 1977, "a new type of treatment and a half-artemisinin lactone published in science bulletin of the world, immediately set the close attention and high value. In October 1981, by the world health organization, the world bank and the United Nations development program sponsored by the chemical treatment for malaria working group meeting was held in Beijing. YouYou was invited to do the carcasses entitled "artesunate chemical research" the report, cause enthusiastic responses, and once again, establish the in this field of research in China advanced level. Traditional Chinese medicine scientific research is big step to the world, and our scientific, standardized, rigorous research promptly to the international academic publication and instructions, and foreign counterparts, the traditional Chinese medicine research for exchange of rapid development, is not only necessary, but is important.

-ZhangJinZhong tianjin university of traditional Chinese medicine